• Santé

Dynamique de l'information génétique | DIG CANCER

  • Unité mixte de recherche

Publié le 27/04/2020 - Mis à jour le 13/12/2024

Équipes

Direction

  • Antonin Morillon

Direction adjointe

  • Valérie Borde

Autres tutelles

  • Centre National de la Recherche Scientifique | CNRS
  • Sorbonne Université

Publications sur HAL - Archive ouverte

Toutes les publications sur HAL
  • Article dans une revue

Expression profile of CASSIOPEIA patients refines prognostic value of MRD negativity in multiple myeloma

Florence Magrangeas, Catherine Guérin-Charbonnel, Victor Bessonneau-Gaborit, Marie Denoulet, Nils Giordano, Aurore Perrot, Cyrille Touzeau, Mark van Duin, Magali Devic, Elise Douillard, Eric Letouzé, Pieter Sonneveld, Jill Corre, Stéphane Minvielle, Philippe Moreau

Long-term follow-up of the CASSIOPEIA trial (NCT02541383) demonstrated superior progression-free survival (PFS) with daratumumab, both in combination with bortezomib, thalidomide, and dexamethasone during induction and consolidation, and during maintenance therapy, in transplant-eligible patients…

Blood Cancer Journal, 2026, ⟨10.1038/s41408-026-01550-7⟩. ⟨hal-05729773⟩

  • Article dans une revue

ATR and TopBP1 oppose to control dormant origin activity and global replication dynamics, providing a first defense against replication stress

Stéphane Koundrioukoff, Nathan Alary, Su-Jung Kim, Thibault Collin, Antoine Toffano, Rodrigo Melendez-Garcia, Xia Wu, Yaqun Liu, Stefano Gnan, Sami El-Hilali, Olivier Brison, Filippo Rosselli, Chun-Long Chen, Michelle Debatisse

Replication stress and resulting genome instability, a major driver of cancer progression, stem from perturbations of replication fork progression. The first defense against this stress is activation of “dormant” replication origins, which supports replication completion. To determine whether ATR,…

Nucleic Acids Research, 2026, 54 (7), pp.gkag315. ⟨10.1093/nar/gkag315⟩. ⟨hal-05720132⟩

  • Article dans une revue

Remodeling of XIST regulatory landscape during primate evolution

Emmanuel Cazottes, Charbel Alfeghaly, Cloé Rognard, Anamaria Necsulea, Agnese Loda, Gaël Castel, Laura Villacorta, Michael Dong, Edith Heard, Irène Aksoy, Pierre Savatier, Céline Morey, Claire Rougeulle

Unraveling how gene regulations are remodeled during evolution is central to understanding how biological processes evolve. We explored this question in the frame of X-chromosome inactivation, a process under strong selective constraint, governed by the XIST lncRNA and its cis-regulators. Using…

Science Advances , 2026, 12 (3), pp.343-356. ⟨10.1126/sciadv.adw5839⟩. ⟨hal-05602599⟩

  • Article dans une revue

Repair of DNA double-strand breaks leaves heritable molecular scars that might shape aging trajectories and cancer risk

Hossein Salari, Chun-Long Chen

Aging tissues accumulate DNA damage, while genome instability is a defining feature of cancer. Despite this shared foundation, DNA damage is still largely viewed as a transient lesion that is either faithfully repaired or converted into a mutation. New evidence challenges this binary view,…

Ageing and Cancer Research & Treatment, 2026, 2026 (3), pp.202609. ⟨10.70401/acrt.2026.0018⟩. ⟨hal-05720117⟩

Toutes les publications sur HAL

Contacts

Adresse postale

Dynamique de l'Information Génétique - DIG CANCER, Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05 France
Adresse physique
Dynamique de l'Information Génétique - DIG CANCER
Institut Curie
26 rue d’Ulm
75248 Paris Cedex 05
France
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