Dynamique de l'information génétique | DIG CANCER

• Article dans une revue

SCANDARE: an institutional dynamic prospective interventional biobanking study

Constance Lamy, Léonard Laurent, Olivier Choussy, Nicolas Pouget, Fabrice Lecuru, Fabien Reyal, Anne-Sophie Plissonnier, Amir Kadi, Frédéric Berger, Joey Martin, Antoine Dubray‐vautrin, Grégoire Marret, Edith Borcoman, Emanuela Romano, Marie Paule Sablin, Luc Cabel, Camille Pasquesoone, Olivier Lantz, Delphine Louis, Doriane Gorret, Ines Dias da Silva, Odette Mariani, Olivier Delattre, Ivan Bièche, Nicolas Servant, Manuel Rodrigues, Jean-Yves Pierga, Romain-David Seban, Elisabetta Marangoni, Antonin Morillon, Clotilde Théry, Charlotte Proudhon, Eliane Piaggio-Flaiszman, Céline Vallot, Fatima Mechta-Grigoriou, Julie Flavius, Célia Dupain, Géraldine Gentric, Anne Vincent-Salomon, Maud Kamal, Christophe Le Tourneau

Purpose: We set up a prospective longitudinal biobanking study answering scientific questions within a regulatory framework and patient-centered approach. We aim in this paper to present the opportunities of such a study, as well as the challenges and the limitations. Patients and methods: SCANDARE…

BMC Cancer, 2026, Online ahead of print. ⟨10.1186/s12885-026-15680-5⟩. ⟨hal-05538607⟩

• Article dans une revue

Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication

Xiaoxuan Zhu, Atabek Bektash, Yuki Hatoyama, Sachiko Muramatsu, Shin-Ya Isobe, Chikashi Obuse, Atsushi Toyoda, Yasukazu Daigaku, Chun-Long Chen, Masato T Kanemaki

Replication origins in human cells form clusters ranging from tens to hundreds of kilobases called initiation zones (IZs), typically located in intergenic regions between active genes. On a larger megabase scale, chromosomes replicate following temporally defined replication timing (RT), where…

Nature Communications, 2025, 16, pp.10069. ⟨10.1038/s41467-025-66278-7⟩. ⟨hal-05406812⟩

• Article dans une revue

Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference

Marie Dorme, Pierre Luciano, Christelle Cayrou, Rakesh Aithal, Julien Vernerey, Valérie Borde, Vincent Géli, Bertrand Llorente, Valerie Garcia

During meiosis, the programmed formation of DNA double-strand breaks (DSBs) by Spo11, a conserved topoisomerase VI family protein, initiates homologous recombination that leads to crossovers between homologous chromosomes, essential for accurate chromosome segregation and genome evolution. The DSB…

PLoS Genetics, 2025, 21 (11), pp.e1011904. ⟨10.1371/journal.pgen.1011904⟩. ⟨hal-05379322⟩

• Chapitre d'ouvrage

Transcriptome-Wide Analysis of the 5′ Cap Status of RNA Using 5′ Monophosphate-Dependent Exonuclease Digestion and RNA Sequencing

Maxime Wery, Ugo Szachnowski, Sara Andjus, Antonin Morillon

mRNA Decay, 2863, Springer US, pp.117-135, 2025, Methods in Molecular Biology, ⟨10.1007/978-1-0716-4176-7_9⟩. ⟨hal-05381367⟩